Sen neurosyfilis forekommer typisk 4 til 25 år efter den primære smitte.

Meningovaskulær syfilis viser sig typisk som apati og epileptisk anfald, generel parese med demens og tabes dorsalis.

Syfilis menes globalt at have smittet 12 millioner personer i 1999, hvoraf over 90 % af tilfældene forekom i udviklingslande.

Efter et drastisk fald, da penicillin blev udbredt i 1940'erne, er antallet af smittede steget i mange lande siden årtusindskiftet, ofte i kombination med hiv-virus.

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Mange personer, der får konstateret sekundær syphilis (40–85 % af kvinder, 20–65 % af mænd) angiver, at de ikke har haft den chanker, der typisk ses i forbindelse med primær syphilis.

Gummatøs syfilis eller sen godartet syfilis forekommer 1 til 46 år efter den primære smitte med et gennemsnit på 15 år.

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Neurosyfilis er en infektion, der vedrører centralnervesystemet.